癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ELMO1 Antibody
Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB, IF, FC, ICC, IP |
|---|---|
| Primary Accession | Q92556 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Other Names | CED12; Ced12 homolog 1; ELMO 1; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 83829 Da |
| Dilution | WB 1:500~1:2000 ICC/IF 1:50~1:200 IP 1:50 FC 1:50 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human ELMO1 |
| Description | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ELMO1 |
|---|---|
| Synonyms | KIAA0281 |
| Function | Regulates the activity of DOCK guanine nucleotide exchange factors (GEFs) (PubMed:11595183, PubMed:12134158, PubMed:32651375, PubMed:38857861). Acts in association with DOCK1, DOCK2, DOCK5 and CRK (PubMed:11595183, PubMed:12134158, PubMed:32651375, PubMed:38857861). Promotes RAC1 activation by DOCK5; the activity is stimulated by RHOG (PubMed:38857861). Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility (PubMed:11595183). |
| Cellular Location | Cytoplasm. Cell membrane. Note=Translocation to plasma membrane seems to be mediated by DOCK1 and CRK |
| Tissue Location | Widely expressed, with a higher expression in the spleen and placenta |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP91741
