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ELMO1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q92556 |
| Other Accession | Q92556 |
| Predicted | Rat, Human, Mouse, Rabbit, Chicken, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 83829 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ELMO. |
| Epitope Specificity | 581-680/727 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 ELMO domain.Contains 1 PH domain. |
| SUBUNIT | Interacts with BAI1 (By similarity). Interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Part of a complex with DOCK1 and RAC1. Part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with PLEKHG6. Interacts with HCK (via SH3 domain). |
| Post-translational modifications | Phosphorylated by HCK (Probable). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | ELMO1 is involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. ELMO1 acts in association with DOCK1 and CRK and was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. It is belived to enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. |
| Gene ID | 9844 |
|---|---|
| Other Names | CED-12; CED12; ELMO-1; 6330578D22Rik; C230095H21Rik; ELMO1s; ELMO1_HUMAN; ELMO1; Protein ced-12 homolog; KIAA0281; ELMO1_MOUSE; engulfment and cell motility 1; engulfment and cell motility 1 (ced-12 homolog, C. elegans) |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ELMO1 |
|---|---|
| Synonyms | KIAA0281 |
| Function | Regulates the activity of DOCK guanine nucleotide exchange factors (GEFs) (PubMed:11595183, PubMed:12134158, PubMed:32651375, PubMed:38857861). Acts in association with DOCK1, DOCK2, DOCK5 and CRK (PubMed:11595183, PubMed:12134158, PubMed:32651375, PubMed:38857861). Promotes RAC1 activation by DOCK5; the activity is stimulated by RHOG (PubMed:38857861). Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility (PubMed:11595183). |
| Cellular Location | Cytoplasm. Cell membrane. Note=Translocation to plasma membrane seems to be mediated by DOCK1 and CRK |
| Tissue Location | Widely expressed, with a higher expression in the spleen and placenta |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97194
