癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ANKRD1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q15327 |
| Other Accession | Q15327 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 36252 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ANKRD1 |
| Epitope Specificity | 185-319/319 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 5 ANK repeats. |
| SUBUNIT | Interacts with YBX1 (By similarity). Interacts with TTN/titin. |
| DISEASE | Defects in ANKRD1 may be a cause of total anomalous pulmonary venous return (TAPVR) . TAPVR is a rare congenital heart disease (CHD) in which the pulmonary veins fail to connect to the left atrium during cardiac development, draining instead into either the right atrium or one of its venous tributaries. This disease accounts for 1.5% of all CHDs and has a prevalence of approximately 1 out of 15'000 live births. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. |
| Gene ID | 27063 |
|---|---|
| Other Names | ALRP; C-193; CARP; CVARP; MCARP; bA320F15.2; Crap; MARP1; MARP; ANKR1_HUMAN; ANKRD1; Cardiac ankyrin repeat protein; Cytokine-inducible gene C-193 protein; Cytokine-inducible nuclear protein; C193; HA1A2; ANKR1_MOUSE; ANKR1_RAT; Cardiac adriamycin-responsive protein; ankyrin repeat domain 1; ankyrin repeat domain 1 (cardiac muscle) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ANKRD1 |
|---|---|
| Synonyms | C193, CARP, HA1A2 |
| Function | May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. |
| Cellular Location | Nucleus |
| Tissue Location | Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99756
