Anti-OX2R / CD200R1 Reference Antibody (Janssen patent anti-CD200R1)

Recombinant Antibody

Anti-OX2R / CD200R1 Reference Antibody (Janssen patent anti-CD200R1) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%
The purity of Anti-OX2R / CD200R1 Reference Antibody (Janssen patent anti-CD200R1)is more than 99.29% ,determined by SEC-HPLC.
Immobilized human CD200R His at 2 µg/mL can bind Anti-OX2R / CD200R1 Reference Antibody (Janssen patent anti-CD200R1)，EC50=0.04025 µg/mL

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	FC, Kinetics, Animal Model
Primary Accession	Q8TD46
Reactivity	Human, Mouse
Clonality	Monoclonal
Isotype	IgG4
Calculated MW	39041 Da

Additional Information
Target/Specificity	OX2R / CD200R1
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	Unconjugated
Expression system	CHO Cell
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.

Protein Information
Name	CD200R1
Synonyms	CD200R, CRTR2, MOX2R, OX2R
Function	Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro- inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.
Cellular Location	[Isoform 1]: Cell membrane; Single-pass type I membrane protein [Isoform 2]: Secreted.
Tissue Location	Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.

Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

Application Protocols

Provided below are standard protocols that you may find useful for product applications.