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Anti-CEACAM5 / CEA / CD66e Reference Antibody (labetuzumab)

Recombinant Antibody

Anti-CEACAM5 / CEA / CD66e Reference Antibody (labetuzumab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-CEACAM5 / CEA / CD66e Reference Antibody (labetuzumab) is 98.53%, determined by SEC-HPLC.
Immobilized human CEACAM5 His Biotin at 2 ug/mL can bind Anti-CEACAM5 / CEA / CD66e Reference Antibody (labetuzumab), EC50=0.009815 ug/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P06731
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	76796 Da

Additional Information
Target/Specificity	CEACAM5 / CEA / CD66e
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	Unconjugated
Expression system	CHO
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	CEACAM5 (HGNC:1817)
Function	Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:10864933, PubMed:10910050, PubMed:2803308). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
Cellular Location	Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Apical cell membrane. Cell surface Note=Localized to the apical glycocalyx surface
Tissue Location	Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.