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JMJD1B Antibody

     
  • 1 - JMJD1B Antibody ASC10967
    Western blot analysis of JMJD1B in rat liver tissue lysate with JMJD1B antibody at (A) 1 and (B) 2 µg/mL.
  • 2 - JMJD1B Antibody ASC10967
    Immunohistochemistry of JMJD1B in rat liver tissue with JMJD1B antibody at 2.5 µg/mL.
  • 3 - JMJD1B Antibody ASC10967
    Immunofluorescence of JMJD1B in rat liver tissue with JMJD1B antibody at 20 µg/mL.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF, E, IHC-P
Primary Accession Q7LBC6
Other Accession EAW62141, 119582545
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 191581 Da
Concentration (mg/ml) 1 mg/mL
Conjugate Unconjugated
Application Notes JMJD1B antibody can be used for detection of JMJD1B by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 51780
Other Names Lysine-specific demethylase 3B, 1.14.11.-, JmjC domain-containing histone demethylation protein 2B, Jumonji domain-containing protein 1B, Nuclear protein 5qNCA, KDM3B, C5orf7, JHDM2B, JMJD1B, KIAA1082
Target/Specificity KDM3B; This antibody will not cross-react with JMJD1A or JMJD1C.
Reconstitution & Storage JMJD1B antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsJMJD1B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KDM3B
Synonyms C5orf7, JHDM2B, JMJD1B, KIAA1082
Function Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.
Cellular Location Nucleus.
Tissue Location Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

JMJD1B Antibody: The jumonji domain containing 1B protein (JMJD1B) was originally discovered as a candidate for the myeloid leukemia tumor suppressor gene. Besides CD34+ cells and acute myeloid leukemia (AML) cell lines, JMJD1B mRNA is highly expressed in liver, heart, kidney, skeletal muscle, and placenta tissues. The JMJD1B gene is localized to a region of chromosome 5q31, which is frequently deleted in myeloid leukemias and myelodysplasias and expression of JMJD1B in a del(5q) cell line results in suppression of clonogenic growth suggesting that JMJD1B may function as a tumor suppressor. In contrast, JMJD1B gene copy number and mRNA expression level was increased in several non-small cell lung cancers indicating that the role of JMJD1B in cancer formation and progression is more complex than originally postulated. At least three isoforms of JMJD1B are known to exist.

REFERENCES

Lai F, Godley LA, Fernald AA, et al. cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins. Genomics2000; 70:123-30.
Hu Z, Gomes I, Horrigan SK, et al. A novel nuclear protein, 5qNCA (LOC51780) is a candidate for the myeloid leukemia tumor suppressor gene on chromosome band q31. Oncogene2001; 20:6946-54.
Baik S-H, Jee B-K, Choi J-S, et al. DNA profiling by array comparative genomic hybridization (CGH) of peripheral blood mononuclear cells (PBMC) and tumor tissue cell in non-small cell lung cancer (NSCLC). Mol. Biol. Rep.2009; 36:1767-78.

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