癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DLD Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a full length recombinant DLD.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P09622 |
| Other Accession | BC018696 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG3 Kappa |
| Clone Names | 2D4 |
| Calculated MW | 54177 Da |
| Gene ID | 1738 |
|---|---|
| Other Names | Dihydrolipoyl dehydrogenase, mitochondrial, Dihydrolipoamide dehydrogenase, Glycine cleavage system L protein, DLD, GCSL, LAD, PHE3 |
| Target/Specificity | DLD (AAH18696, 1 a.a. ~ 509 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | DLD Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes the L protein of the mitochondrial glycine cleavage system. The L protein, also named dihydrolipoamide dehydrogenase, is also a component of the pyruvate dehydrogenase complex, the alpha-ketoglutarate dehydrogenase complex, and the branched-chain alpha-keto acide dehydrogenase complex. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency.
REFERENCES
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. Asano K, et al. Nat Genet, 2009 Dec. PMID 19915573.Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. UK IBD Genetics Consortium, et al. Nat Genet, 2009 Dec. PMID 19915572.Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation. Martins-de-Souza D, et al. BMC Psychiatry, 2009 Apr 30. PMID 19405953.Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Silverberg MS, et al. Nat Genet, 2009 Feb. PMID 19122664.The role of amino acids T148 and R281 in human dihydrolipoamide dehydrogenase. Wang YC, et al. J Biomed Sci, 2008 Jan. PMID 17960497.
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