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>   首页   >   产品   >   一抗   >   癌症   >   FAP Antibody (monoclonal) (M01)   

FAP Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant FAP.

     
  • 1 - FAP Antibody (monoclonal) (M01) AT1998a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
  • 1 - FAP Antibody (monoclonal) (M01) AT1998a
    FAP monoclonal antibody (M01), clone 1E5 Western Blot analysis of FAP expression in HepG2 ( (Cat # AT1998a )
  • 1 - FAP Antibody (monoclonal) (M01) AT1998a
    Western Blot analysis of FAP expression in transfected 293T cell line by FAP monoclonal antibody (M01), clone 1E5.

    Lane 1: FAP transfected lysate(87.7 KDa).
    Lane 2: Non-transfected lysate.
  • 5 - FAP Antibody (monoclonal) (M01) AT1998a
    Immunoprecipitation of FAP transfected lysate using anti-FAP monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with FAP MaxPab rabbit polyclonal antibody.
    U0007), and immunoblotted with FAP MaxPab rabbit polyclonal antibody." href="/assets/uploads/products/200811/AT1998a_IP_1.jpg">
  • 10 - FAP Antibody (monoclonal) (M01) AT1998a
    Detection limit for recombinant GST tagged FAP is approximately 0.1ng/ml as a capture antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IP, E
Primary Accession Q12884
Other Accession BC026250
Reactivity Human
Host mouse
Clonality monoclonal
Isotype IgG2a Kappa
Clone Names 1E6
Calculated MW 87713 Da
Additional Information
Gene ID 2191
Other Names Prolyl endopeptidase FAP, 170 kDa melanoma membrane-bound gelatinase, Dipeptidyl peptidase FAP, Fibroblast activation protein alpha, FAPalpha, Serine integral membrane protease, SIMP, Surface-expressed protease, Seprase, Antiplasmin-cleaving enzyme FAP, soluble form, APCE, 3421-, FAP (HGNC:3590)
Target/Specificity FAP (AAH26250, 525 a.a. ~ 624 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
IP~~N/A
E~~N/A
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsFAP Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.

REFERENCES

1.Fibroblast Activation Protein (FAP) Is Essential for the Migration of Bone Marrow Mesenchymal Stem Cells through RhoA Activation.Chung KM, Hsu SC, Chu YR, Lin MY, Jiaang WT, Chen RH, Chen XPLoS One. 2014 Feb 13;9(2):e88772. doi: 10.1371/journal.pone.0088772. eCollection 2014.2.Extracellular Hsp90 mediates an NF-κB dependent inflammatory stromal program: Implications for the prostate tumor microenvironment.Bohonowych J, Hance M, Nolan K, Defee M, Parsons C, Isaacs JProstate. 2013 Dec 16. doi: 10.1002/pros.22761.3.Differential impact of TGF-beta and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion.Denys H, Derycke L, Hendrix A, Westbroek W, Gheldof A, Narine K, Pauwels P, Gespach C, Bracke M, De Wever O.Cancer Lett. 2008 Aug 8;266(2):263-74.4.Fibroblast activation protein and chronic liver disease.Wang XM, Yao TW, Nadvi NA, Osborne B, McCaughan GW, Gorrell MD.Front Biosci. 2008 Jan 1;13:3168-80.

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