癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KHSRP Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant KHSRP.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | Q92945 |
| Other Accession | NM_003685 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 4C10 |
| Calculated MW | 73115 Da |
| Gene ID | 8570 |
|---|---|
| Other Names | Far upstream element-binding protein 2, FUSE-binding protein 2, KH type-splicing regulatory protein, KSRP, p75, KHSRP, FUBP2 |
| Target/Specificity | KHSRP (NP_003676, 151 a.a. ~ 239 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | KHSRP Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).
REFERENCES
Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis. Michlewski G, et al. Nat Struct Mol Biol, 2010 Aug. PMID 20639884.Dishevelled-KSRP complex regulates Wnt signaling through post-transcriptional stabilization of beta-catenin mRNA. Bikkavilli RK, et al. J Cell Sci, 2010 Apr 15. PMID 20332102.KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cells. Nechama M, et al. BMC Cell Biol, 2009 Sep 23. PMID 19775426.Overexpression of far upstream element binding proteins: a mechanism regulating proliferation and migration in liver cancer cells. Malz M, et al. Hepatology, 2009 Oct. PMID 19585652.The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Trabucchi M, et al. Nature, 2009 Jun 18. PMID 19458619.
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